PATIENT’S STORY

Autistic child from London improves after stem cell therapy

This nine year old was a male child from London. He was born on the mother’s 34th week; it was a normal delivery but prolonged labour. The baby did not cry immediately after birth and weighed 2.5 kgs. He was kept under observation for five days. He had a history of normal milestone development. His speech had developed and he could say words like ‘pasta’, ‘biscuit’ and ‘juice’. He was a bright child and had good grasping power.

But by the age of two and a half years, his parents started noticing some changes in him. He had poor social interaction and he started regressing with his speech slowly.
They consulted a psychiatrist and he was diagnosed with a case of Autism at the age of four and a half years. Ever since that, he was attending a normal school with a shadow teacher. Later at the age of six and half years, he was sent to a special school and received regular occupation therapy and speech therapy once a week. His mother was conscious about his problems and tried every possible treatment.

During this tough ordeal, she came across Stem Cell Therapy as a treatment option for Autism through the internet. She contacted NeuroGen Brain and Spine Institute to know more about the therapy. And the rest, they say, is history.

They reached India on the last week of September. The normal checkup was conducted based on his condition. He was admitted on 30th of September 2013 and his case was thoroughly examined. According to his mother’s verdict he had the following symptoms- Poor social interaction, fleeting eye contact, inappropriate emotional responses like irrelevant laughing and crying without any reason, motor mannerisms like finger fidgeting, rocking etc. smelling objects, presence of unusual noises, fearful of loud noises, weak fine motor skills, poor – fair perceptual and cognitive skills.

On a closer examination, he was found to had Tactile, Vestibular, Proprioceptive and Olfactory Hyposensitive and Auditory Hypersensitive.Although he was independent for all his activities of daily routine, his mother was mainly concerned about his difficulty in buttoning, zipping and lacing even prior to the treatment. Upon assessment, his Functional Independence Measure score was 74.

On a closer study, he scored 117(70%) on ISSA {Indian Scale for Assessment of Autism} and 34 on Childhood Assessment Rating Scale.
On 1st of October, he went through stem cell therapy and after which he was under regular rehabilitation for one month. He was under several therapy sessions like Occupational Therapy, Speech Therapy and Psychological Session for six days a week for one month.

On the final day of therapy, he had the following improvements as reported by his parents

Improvement in Perceptual and Cognitive Skills:

  • Eye contact was more meaningful.
  • Overall attention and concentration improved especially while speaking to him.
  • Overall awareness had increased.
  • He could swing on his own (which his parents were trying to teach him since 5 years).
  • He could point out his body parts like eyes, ears and nose.
  • He identifies A – Z and can place it in order in the board.
  • He identifies shapes and can insert in the 3D box.
  • He could now identify red and yellow colour and also he could do sequencing of beads and flower links.
  • He can identify red and yellow colour with shapes.

Improvement in Sensory Problems

  • Earlier he would pick up his T shirt and ask his parents to scratch his stomach which has completely stopped now.
  • His auditory hypersensitivity has reduced considerably. He could tolerate the sound of a baby crying in the room, also people talking around him. Ear closing was minimal during the session and outdoors.
  • Motor mannerisms had reduced in public places.

Improvement in Social Interaction and Communication

  • He could now play ball throwing and catching game in a group with his parents and therapist.
  • Previously when they were on Skype with his relatives he needed to be forced to interact with their relatives but now he points towards them and kisses them.
  • He uses to grab his parent’s attention by vocalizing.
  • He now tries to convey his needs by pointing accompanied by making noise.
  • He had spontaneous vocalization, he says |a|on demand.

Improvements in Activities of Daily Living

  • He can now button his shirt; also he buttoned his mother’s Shirt.
  • He can now cross and make an initial knot for tying shoe lace.
  • His fine motor skills have improved.

His parents were extremely happy and delighted on seeing his improvements. They are in regular contact with all the professionals at NeuroGen Brain and Spine Institute via email.

What the patient’s parents had to say?

Recently they sent a mail saying,” he is doing well on most days. I am following all your commands. He learned how to zip up completely since we arrived. He can now do five colours threading and sequencing. Buttoning process has also improved. Making straight lines vertically and horizontally without a ruler and he is holding the pen firmly and trying to write the letter O. He is also trying to colour inside the shapes without play dough. He is doing fine for now, still need to brush up on more. I am struggling to teach him to tie the shoes lace, but I am taking it easy. Slowly we’ll get there. I keep taking him to roller-skating. Today was his first ice-skating lesson and he did quite well. Tomorrow I am taking him to swimming classes and in the mean time I am trying to organize different play groups (art and craft etc).”

He is almost like a normal child

The child was born of a full term C-section delivery. He cried immediately after birth and weighed 7.5 pounds. He had a history of delayed milestones and frequent falls while walking between 2 and 7 years of age. He was examined at six years of age and reportedly having a borderline intelligence level with 72 IQ.
He had to undergo regular occupational therapy and speech therapy at the time of diagnosis. In the year 2011, his family learnt about Stem Cell Therapy as a treatment option for Autism and Intellectual Disability. He was primarily examined by every professional.

The main concerns stated by his grandmother was poor eye contact, blurred speech, drooling, poor fine motor activity, poor problem solving, delayed reaction time and hypersensitivity to sound.
On further studying his case, we found that he had generalized hypotania, poor standing balance and coordination. But again like any normal kid, he could remember dates accurately. For example, if he was asked something about what day it was mentioning a particular date; he would give a prompt and correct answer.
He scored 85 on Indian Scale for Assessment of Autism {ISAA}, 15 on CARS {Childhood Autism Rating Scale}.
Functionally he was independent for all his Activities of Daily Living 117.

When he came for his first follow up, the following improvements were seen

Improvement In cognitive and perceptual skills

  • He does things willingly, earlier he required continuous prompts.
  • He could give his opinion in family matters.
  • His grasping power has improved.

Improvement in Fine Motor Skills

  • He can pick up small objects with fingers.
  • His balance also improved.
  • On assessment his ISAA score reduced from 84 to 75.
  • He was advised to continue all the exercises and treatment protocol.
  • Later he came for his next follow up after 2 years of Stem Cell Therapy. During which his grandmother reported that he had many improvements after 1 year of stem cell therapy. Also the statement given by grandmother was, “he is as good as a normal child”.

He presented with following improvements after 1 year of stem cell therapy

Improvement in Oro – motor skills

  • His drooling has reduced considerably.
  • His clarity of speech has improved.

Improvement in Cognitive, perceptual and Social Skills

  • His drooling has reduced considerably.
  • His clarity of speech has improved.

Improvement in Cognitive, perceptual and Social Skills:

  • He behaves more mature.
  • He now understands the importance of exercises and thereby does it on his own.
  • He maintains eye contact with all the guests who come home.
  • His vocabulary has improved, now he knows capital of all countries.
  • He can now fill the bank slip on his own and also go to the bank and deposit money.
  • He can now translate words from Marathi to English language.
  • He can now relate people and understands everything.
  • He can now argue with his grandmother.
  • He can imitate.
  • He makes paper bags and sell it to a medical store and monthly earns around Rs 600/-
    He has been offered to work as an assistant in his therapy centre for which he will get stipend.

Improvement in Fine Motor Activities:

  • He can now button his shirt and do zipping.
  • While making paper bags, he makes with lot of precision.

Improvement in sensory Issues, Balance and Co – Ordination

  • Hypersensitivity to sound has reduced. Now he only gets scared of crackers.
  • His in coordination has reduced.
  • The grandmother at the time of follow up just mentioned that, “he is almost like a normal child”.
  • On assessment his ISAA Score reduced from 75 to 69. (From Mild Autism to No Autism)

What the patient’s parents have to say?

Recently they sent a mail saying,” he is doing well on most days. I am following all your commands. He learned how to zip up completely since we arrived. He can now do five colours threading and sequencing. Buttoning process has also improved. Making straight lines vertically and horizontally without a ruler and he is holding the pen firmly and trying to write the letter O. He is also trying to colour inside the shapes without play dough. He is doing fine for now, still need to brush up on more. I am struggling to teach him to tie the shoes lace, but I am taking it easy. Slowly we’ll get there. I keep taking him to roller-skating. Today was his first ice-skating lesson and he did quite well. Tomorrow I am taking him to swimming classes and in the mean time I am trying to organize different play groups (art and craft etc).”