This case is of a 12 year old girl suffering from a rare case of muscular dystrophy. She comes from a family that has a history with muscular dystrophy. When she turned nine, the weakness in her legs worsened. She started facing difficulty in climbing up the stairs and getting up. Her condition worsened when this same weakness spread to her arms and face leaving her almost expressionless. Her speech was indistinct and she faced difficulty to close her eyes and pursing her lips. She was struggling to carry on with her daily activities. She was not sociable and did not show interest in pursuing any outdoor activities. Such was her case when her case first came to NeuroGen.
When we studied her case, we noticed that her muscles were tender and weaker compared to other kids her age. Her cheek muscles were particularly weak. The study of the muscles, EMG showed the prime pathology and confirmed the diagnosis. Furthermore, the MRI scan showed that the muscle fibers were restored by fat tissue as the muscles were of normal size and their strength had decreased. We carefully studied the strength of each muscle. It was detected that her weakness were more pronounced in the left upper limb and left lower limb. We ascertained that the muscles needed more attention and we planned our treatment accordingly.
She had to undergo a stem cell therapy when we finally injected the stem cells in the spinal fluid and muscles like Frontalis, Orbicularis oculi, Nasalis, Orbicularis oris, Levator superior, Levator Inferior, Abdominals, Deltoid, Rhomboids, Adductor of shoulder, Glutei and Adductor of hip. After injecting the stem cells, the patient had to undergo rigorous therapy. She was assigned with various exercises to strengthen the weak muscles. These exercises help her to perform the daily activities in an easier way. Activities like rolling on bed, lifting up her waist while in bed, getting up in all four’s position and strengthening of all muscles of respiration. Occupation therapists worked to lessen her difficulty with using arms for overhead activities and hand movements in finer activities. All these exercises were also given to be performed at home. She was given a CD containing these exercises so they could carry on with the regular performance.
Improvements seen in the patient post stem cell therapy
- The blood marker of her disease, enzyme, CreatininePhsopho Kinase (CPK) showed a great reduction.
- The concentration of this enzyme in blood increases with more and more muscle damage. Reduction in its levels suggests reduced muscle damage.
- The enzyme levels in blood before the treatment were 425 units which reduced to 139 units.
After three months when she visited us, some of the leg muscles showed improvement. She felt more energetic. Her facial expressions improved. She was more cheerful. She could whistle closing her lip properly. It was much easier for her to climb the stairs. She could speak clearly. She could walk much better with reduced frequency of falls.
What the patient’s parents have to say?
“We as a family have a long history with muscle dystrophy and it was really sad to see our daughter suffer from this for the longest time. It was sad to put our daughter through this ordeal. We were hopeful of her recovery but at the same time very broken. Today we are happy to declare that our daughter is a living miracle. Her leg muscles have shown massive improvement. We have never seen her so energetic and cheerful. Her whole energy is infectious. Her facial expressions have improved. She can even whistle closing her lip properly. She is able to climb up and down the stairs. Also, we are able to make out her verbal words clearly. We could not have asked for more.”