The chief line of the nerve tissues connecting the brain and the vertebral canal is the spinal cord where the spinal nerves surfaces. When a spinal cord gets injured, it sometimes leads to permanent damage to bodily functions. Injury to the spinal cord occurs when a major damage to any spinal nerve occurs at the spinal canal. When the damage that occurs to the spinal cord is unsurpassable defects in the sensory, motor and reflex messages are detected after a spinal cord injury. Going by the context, a person will not be able to function properly and the condition worsens when the level of injury is higher.


The intensity of the damage to the nerve fibers is not measured through the severity of the spinal cord injury. In most cases, this type of injury can give rise to certain clinical occurrences.

These symptoms listed below:

  • Trouble with walking and proper movement
  • Inability to differentiate sensations and feel heat, cold and touch
  • Loss of the control of the bowel or bladder movements
  • Moments of inflated reflex actions or seizures
  • Unnatural sexual function and sensitivity
  • Moments of growing numbness and tingling to extreme
  • Signs of breathing problems and coughing

A spinal cord injury may be termed as complete or incomplete based upon the seriousness of the injury level. If a person undergoes a complete injury, then they will not be able to control over their movements, while a person that undergoes an incomplete injury may experience some sensory activities underneath the injured area. In case of a paralytic condition due to an injury in the spinal cord, then it can be termed as quadriplegia and paraplegia. When a person’s arms, legs, hands and pelvis gets affected then it is referred to quadriplegia and if paraplegia occurs, it can harm the trunk, legs and pelvis region.

Causes of Spinal Cord Injury

Spinal cord injury occurs due to the severity of the damage to the vertebrae, ligaments or disks of the spinal column. The injury can be traumatic and non-traumatic. If a person experiences an unexpected harm to their spine in the form of dislocations, compressing of the vertebrae and fractures, then it leads to another form of traumatic injury.

The most common cases leading to traumatic spinal cord injury is listed below:

  • Motor vehicle accidents
  • Football
  • Falls
  • Gymnastics
  • Violence
  • Unsupervised sport activities

On the other hand, non-traumatic spinal cord injury may occur because of arthritis, cancer, inflammation, infections or spinal disk deterioration.

Treatment for Spinal Cord Injury

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A spinal cord injury raises the risk for the nerve cells to get damaged or inflamed. A number of chemical carriers emits out from the area of the damaged nerve cells and thereby exerting the body immune cells to the damage area. It directly impacts on the healthy cells which lead to more chances of inflammation.

Objective radiological Improvements (Brain FMRI) after stem cell therapy in spinal cord injury

Pre stem cell therapy FMRI showing no activity in the frontal areas of the brain

Post stem cell therapy FMRI showing new activity in the frontal areas of the brain suggesting a positive response to the treatment

For patients who have lost all hope in recovering from a spinal cord injury, the stem cell therapy is the best answer. It helps to improve all the functionary systems of the sensory and ambulatory of patients with paraplegia and quadriplegia.

About Stem Cell Therapy

If a person is treated within a time period of six months before any signs or symptoms occur, then it lowers the risk of inflammation. It facilitates neuroprotection and neuroregeneration to form fresh synapses and axonal sprouting that helps in the growth formation of newer neurons. We adopt the use of stem cell therapy in certain cases to improve the growth of the prevailing tissues by angiogenesis and neuro-protection.

Action potential happens when the latent source of the cells quickly rise and fall. It also leads to a repair and renewal process of cells like neurons and glial which transmits electrochemical impulses through stem cell therapy. The cells transmit and acts like a carrier of information linking the brain and the spinal cord. Additionally, it helps to regenerate the myelin sheath and boost the alacrity of the nerve conveyance. Cell tissues are regenerated to form blood supply through the discharge of neurotrophic factors, cytokines and other molecules. All these factors help in generating a new structural order for newer nerve cells at the damaged area.

The NeuroGen Outcome

People have been disillusioned regarding the after effects of a spinal cord injury and in thinking that they will remain confined to bed for life. But with the advancement of stem cell therapy, patients are given a new leash of life and get their old life restored.
Till date, we have treated more than 651 patients with a spinal cord injury and have helped them get back to their feet.
There are innumerable complication cases that an individual with spinal cord injury faces. But after stem cell therapy, a patient have seen improvement in trunk control, standing balance, sitting balance, spasticity, sensation, bladder movements and postural hypotension.

In a total of 110 patients that we treated with an acute thoracolumbar injury and paraplegia, 91% demonstrated improvement in their clinical symptoms.

In a total of 50 patients that we treated with cervical injury and quadriplegia, 74% of the patients have shown improvements in their clinical symptoms.

There is a correlation between the improved motion of the nerve tissues in the injured areas and the improvements condition of our patients. It can be conceived with the help of the Functional Magnetic Resonance Imaging scanning process. By FMRI (Functional Magnetic Resonance Imaging), we mean the knowledge of neuroimaging tools that facilitates the activity in the brain area.

Conventional treatment options

The injury caused to the tissues often leads to permanent damage even if the spinal cord and the brain are able to renew itself but still its regenerating process is not capable enough. At present, medical science is working towards restoring the spine injury however no medical leads have been found to regenerate the injury that occurs in the spinal cord. Treatment options like surgery are available to improve the condition of the patient. But patients need to go for a rehabilitation session since the pain might not alleviate even after surgery. They can make use of assisted devices to help them carry on with their normal activities. Along with physical therapies with counseling, patients can nurture their hope to improve.

Case Studies : Spinal Cord Injury

Spinal Cord Injury patient performs at dance show

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Her FIM score increased
from 53 to 66

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41 year old Spinal Cord Injury
patient walks with the assistance
of just one in a week

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Shift from indwelling catheter
to CSIC after 3 years

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Reduce disability and Improve Ability

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Ex Miss Wheelchair Contestant, 26 year old Komal Bora, victim of spinal cord injury, is all set to rock the stage this year with a duet performance with her husband.

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Your most common questions answered

What is the difference between paraplegia & Quadriplegia?

Paraplegia can be defined as losing control of movement and sensation from the waist down whereas the term Quadriplegia includes loss of function in the upper body, arms and hands.

What is the difference between a complete and incomplete injury?

By Complete injury we mean injuries that have effectively no transmission of signals across a spinal cord lesion and no voluntary control of movement or perception of sensations below the lesion. Whereas by Incomplete’ injuries we mean, the undamaged pathways across the spinal cord lesion. The outcome can be extremely changeable depending on which parts of the spinal cord are damaged.

Do people with SCI ever get better?

There is some possibility for some function to recuperate after the spinal cord injury. It is important that the main measures to reduce the injury should be taken immediately. This helps in preventing secondary injuries and reduces severity of the problem.

Is there a cure for SCI?

There are chances of injuries getting healed after a period of time in some cases. But the same cannot be said about the central nervous system. The injury caused on the spinal cord and brain takes time to heal. An effort can be made to regenerate new cells by stopping the mechanisms that end neurons from growing.

What is life expectancy after SCI?

A spinal cord injury will not decrease the mortality rate of a person. Some complications may occur if proper care is not taken in time. There are problems that occur like chronic kidney failure, chest infections and deep vein thrombosis. If all the complications are treated in time, the minor issues can be thwarted.

What care does a patients/caretaker of a SCI need to take after the injury? What are the “MUST KNOWS”?

We keep our treatment focus on surgery or fixing of the vertebra. Caretakers and patients need to be counseled about, what to expect after injury. They should understand that the injury extends over a period of six months. At the initial stage, the hands and legs would be loose or flaccid. At a later stage, it becomes stiff and spastic. It should be followed up with physiotherapy or rehabilitation session. Remember to turn over the patient every two hours to prevent bedsores. The patients need to drink a lot of liquid in order to prevent urinary tract infection.

How sexuality is affected by spinal cord injury and is it possible to conceive a child?

Sexual function of a patient gets generally affected with a spinal injury. It is possible to revitalize the patient, with the help of an andrologist. In our experience, we have observed that with the help of medicines the males with sexual dysfunction have been able to have intercourse.

What is the role of rehabilitation and how can NeuroGen help us?

The essential role of rehabilitation is to help patients with spinal cord injury and help them become more independent with their daily activities.

What is the role of stem cell therapy in spinal cord injury?

Stem cells are possible for treating spinal cord injuries. Transplantation studies in animals have shown that a transplantation of stem cells or stem-cell-derived cells may add to spinal cord repair by: The interchangeability of the nerve cells that may have passed on owing to the Producing newer cells that restructure the insulating nerve sheath
To avert an increase in the injury level by repressing the harmful inflammation after the occurrence of an injury

How does stem cell therapy work?

The biological task of stem cells is to replenish and renew damaged cells. Stem cell therapy exploits this role by administering these cells in high concentrations directly in and around the damaged tissue, where they move forward with its self healing and repair.

Are there ethical concerns surrounding adult stem cell research and therapy?

No, there are no ethical concerns surrounding adult stem cell research and therapy. Ethical concerns are mostly occurs through the use of embryonic cells. Our therapy consists of using cells which are taken out from the patient’s own body and it is free from ethical concerns.

Is the treatment painful?

No, the treatment is not painful as the therapy is done under local anesthesia and a mild sedation. There is no major pain or discomfort during or after the procedure.

Does the treatment have any side effects?

The whole therapy session is safe and till date none of our patients have shown any signs of neurological deterioration. In rare cases, side effects like headache for 3-4 days, neck or back pain, vomiting, mild rash or pain at the area of bone marrow aspirations may arise. Some unexpected medical complication can occur but that is just a possibility.

How long will it take me to know that I have benefitted from the treatment?

This may vary from patient to patient. Some patients makes a speedy improvement by 3-6 months while in some cases patients take several months or years together to heal. And there are some patients that recover even before their discharge

Is the transplantation of the stem cells done once or more than once?

This will depend on the condition of the patient. If the patient shows signs of improvement after the first surgery then a second transplantation may be suggested by a team of experts. The second transplantation can transpire anytime between 3-6 months of the first therapy.

Can other treatments be taken at the same time?

We will have to review the entire dose of medication before coming upon a decision. Generally we do allow the patients to continue their other medication. But it is better to consult a doctor beforehand

How much improvement will the patient have?

Since this is a new therapy and not an existing one, it is difficult to say. It will depend on several factors like the age of patient, type of illness, duration of illness and extent of rehabilitation taken after the treatment.