STROKE EXPLAINED

Strokes occur because of the blockage of blood supply and blood vessel within the brain. When a person gets a stroke, treatment must be immediately sought as it can lead to more serious clinical conditions. If a patient is attended to on time, then it reduces the chances of more complications.

Symptoms

  • One sided weakness or numbness on the face, arm, or leg
  • Both eyes or one will experience loss of vision or dimming
  • Unable to comprehend things and loss of speech
  • Severe headaches that remains unidentifiable
  • No balance during movement leading to a new symptom

Several functions like sensorimotor, perceptual, emotional, behavioral, memory intelligence, speech and language function includes certain degree of neurological involvement ultimately affecting daily activities.

Conventional treatment options

If a person has suffered a stroke, then immediate treatment procedure should follow up so that brain does not suffer more damage. Primarily, doctors can put a patient under oxygen and keep them under an intravenous drip to help patients restore health and boost their fluid level.

There are different causes of stroke and each stroke has a different diagnosis. Suppose a person gets an ischemic stroke, then generally he is given an aspirin to avert a second attack. Then again, if the stroke occurs due to a clot formation, then drugs like altepase may help dissolve the clot and ward off paralytic symptoms. In case of an obstruction in the artery of the neck, then surgery is the option to prevent a stroke from occurring again. This process is known as carotid endarterectomy.
If a person suffers a stroke and it causes a brain damage, then the damage is irreversible. The patient can go through a rehabilitation program to overcome the damage caused and resume with normal activities. Therapies such as physiotherapy, occupational therapy and speech therapy is required for the proper movement of the body. Till date, there are rare cases that patients recovered completely from a stroke attack. Improvements are possible if a patient takes care of their diet regime and exercise routine to recover a brain attack.

Causes of Stroke

There are three kinds of strokes namely ischemic stroke, hemorrhagic stroke and transient ischemic attack. Ischemic stroke is caused due to an artery blockage, a hemorrhagic stroke may be caused due to a leak or a burst of blood vessel and a transient ischemic attack is caused due to a momentary interference in the blood flow of the brain.

Ischemic stroke-

It takes place due to the obstruction of blood clots to the blood flow in the brain. Strokes or heart diseases can occur due to a plaque buildup in the arteries. It blocks the normal flow of blood and increases the threat of a stroke. As we mature, our arteries also weaken leading to more risk. Some factors like smoking, high blood pressure, high cholesterol levels, excessive uptake of alcohol and heart attack can add to the problem. An irregular heartbeat can be another cause of ischemic stroke.

Hemorrhagic stroke-

It occurs from a damaged vessel that raptures and bleeds into the brain. There is a blood build up and it constricts the region of the brain tissue. A hemorrhagic stroke can deteriorate the brain arteries and lead to high blood pressure. In a more serious case, injury can lead to brain bleeding ultimately leading to blood clot formation. There are other risk factors involved like being overweight, smoking, excessive alcohol intake, lack of exercise and stress.

Transient ischemic attack-

This stroke is comparable with stroke symptoms and it is known as a mini stroke too. Transient ischemic attack can occur due to a temporary reduction in the brain blood supply. This kind of attack does not leave behind a permanent damage as the blockage is momentary.

Treatment For Stroke | Quick Look

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STEM CELL THERAPY FOR STROKE

The application of mesenchymal stem cells has increased hope for stroke therapy. The functional recovery of the animal models of ischemic stroke indicates growing number of facts that mesenchymal stem cells promote. Making a distinction with the human mesenchymal stem cells into cells can transfer along the paths that bear a resemblance to neuronal progenitor cells.

Objective Radiological evidence of improvement after stem cell therapy in a case of stroke

Pre and Post stem cell therapy PET-CT scans of a 68 year old man with stroke

Pre stem cell therapy PET CT

scan showing green area is the area of normal metabolism, blue area is the penumbral area, which is the area around the main area of stroke and shows hypo metabolism. The black area is the gliotic area, which is the main stroke area.

Post stem cell therapy PET CT

scan showing reduction in the black gliotic area in the left hemisphere and is turning towards blue, depicting improved metabolism than before. There is increase in the green are and reduction of the blue area, which tells us that there is increased metabolism occurring in the areas affected by stroke.

stroke graph

 

Stoke Treatment Center in Mumbai

About Stem Cell Therapy

Additionally, the generation of the mononuclear fraction consists of numerous cells that can emit out cytokines and trophic factors. All these help in generating the supply of blood, neuroprotection and neuroregeneration in areas that are affected.
The mesenchymal stem cells can do without invasive operations. It is well suited and does not have any ethical issues since the cells are generated from the bone marrow. Furthermore, making use of the patient’s own bone marrow cells averts all immune related problems.

These positive results have allowed the doctors, researchers and scientists to accept the potentialities of stem cell therapy to improve the state of the people affected with stroke.

The NeuroGen Outcome

We cannot bring relief to the paralytic patients regardless of having the best medical options, newer neuro protective drugs and extensive rehabilitation is the common belief with brain injuries. But with the discovery of stem cell therapy, this conception is soon changing.

We have treated over 100 patients with our commitment and dedication to bring improvement in our patients’ living conditions. Many patients that came for treatment had reached a plateau stage regarding the improvements in their symptoms. Our patients have demonstrated incredible improvements after the stem cell therapy. Improvements in upper limb activity/hand functions, lower limb activity, trunk activity, balance, higher mental functions/speech, ambulation and activities of daily living are seen. It helps patients to resume with their normal activities and get back to being independent.

The research for patients showed that 51.8% of patients showed considerable improvements and 29.6% of patients showed moderate improvements and another 11.1% of patient observed mild improvements. It leads towards a promising future.
These improvements seen in our patients are not just restricted to the functional and symptomatic changes but it is always a step ahead. Repairing the damage in the stroke areas of the brain as studied in the PET-CT scans is administered by the stem cells during the therapy session.

Watch the success story of our patient treated for Stroke

Case Study : Stroke

Functional Improvements Seen
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Your most common questions answered

What causes a stroke?

A stroke can strike at any hour and can occur as a consequence to loss of blood flow to the brain that causes cells to die. It is sometimes known as brain attacks. The damage that cell death causes to the brain increases with time and it is important to seek help right away if someone a stroke strikes someone.

Are there different types of stroke?

There are two different types of stroke. One is ischemic stroke and the other is hemorrhagic stroke. An ischemic stroke is caused due to the blockage of an artery or blood vessel. About 80% of the strokes are ischemic. The other 20% forms the hemorrhagic strokes and it takes place when the blood vessel or artery splits and leaks into the brain.

What are the risk factors for a stroke?

The common risk factors for a stroke are uncontrolled high blood pressure, constant smoking, obesity or being overweight, poor dietary habits, sedentary lifestyle or physical inactivity, chronic uncontrolled diabetes, high cholesterol and triglyceride levels.

What are the symptoms of a stroke?

There are certain symptoms of a stroke that one need to look out. Signs like sudden numbness or weakness of face, arm, or leg on one side of the body, sudden confusion, trouble speaking or understanding, sudden difficulty seeing or loss of vision, sudden trouble walking, dizziness, or imbalance. There could also be unexpected unconsciousness connected with it.

What is the extent of recovery that can be achieved after the stroke?

The extent of recovery that can be achieved after the stroke are varied. A stroke does harm to the brain cells. The degree of the brain damage and the size of the stroke are directly connected to the extent of the impairments or paralysis. People suffering a minor stroke may have only slight impairments such as a weak arm or leg. However a massive stroke can cause a person to lose the ability to read, write, or speak. It may also result in paralysis.

What kind of treatment is available for stroke patients?

Treatments are specified depending on the type and severity of the stroke. For example, if the patient has suffered an ischemic stroke, then an immediate therapy must be given to him. On the other hand, if the patient suffers a hemorrhagic stroke, immediate therapies that include medication and surgery is given to him

What kind of rehabilitation is available for stroke victims?

Rehabilitation is a significant aspect of stroke care. At NeuroGen, the patients can provide the most comprehensive and holistic stroke rehabilitation. Our rehabilitation program includes speech therapy, physical therapy, and occupational therapy.

How does stem cell therapy help in stroke, especially in comparison with regular rehabilitation?

Stem cell therapy restores the brain damage which is giving less performance after suffering from a brain stroke. It works well with the rehabilitation process. It helps to speed up the recovery process.

How does stem cell therapy work?

The biological task of stem cells is to repair and regenerate damaged cells. Stem cell therapy exploits this function by administering these cells in high concentrations directly in and around the damaged tissue, where they advance its self healing and repair.

Are there ethical concerns surrounding adult stem cell research and therapy?

No, there are no ethical concerns surrounding adult stem cell research and therapy. Ethical concerns are mostly occurs through the use of embryonic cells. Our therapy consists of using cells which are taken out from the patient’s own body and it is free from ethical concerns

Is the treatment painful?

No, the treatment is not painful as the therapy is done under local anesthesia and a mild sedation. There is no major pain or discomfort during or after the procedure.

Does the treatment have any side effects?

The whole therapy session is safe and till date none of our patients have shown any signs of neurological deterioration. In rare cases, side effects like headache for 3-4 days, neck or back pain, vomiting, mild rash or pain at the area of bone marrow aspirations may arise. Some unexpected medical complication can occur but that is just a possibility.

How long will it take me to know that I have benefitted from the treatment?

This may vary from patient to patient. Some patients makes a speedy improvement by 3-6 months while in some cases patients take several months or years together to heal. And there are some patients that recover even before their discharge

Is the transplantation of the stem cells done once or more than once?

This will depend on the condition of the patient. If the patient shows signs of improvement after the first surgery then a second transplantation may be suggested by a team of experts. The second transplantation can transpire anytime between 3-6 months of the first therapy.

Can other treatments be taken at the same time?

We will have to review the entire dose of medication before coming upon a decision. Generally we do allow the patients to continue their other medication. But it is better to consult a doctor beforehand

How much improvement will the patient have?

Since this is a new therapy and not an existing one, it is difficult to say. It will depend on several factors like the age of patient, type of illness, duration of illness and extent of rehabilitation taken after the treatment.