DEMENTIA EXPLAINED

Dementia is not a disease disorder that can be well defined. It leads to an acute deterioration in the mental capacity slowing down the thinking and social capabilities impeding normal living. In a wider context, we can term it as a group of symptoms that occurs due to some brain disorders. Another common symptom of dementia is memory loss. But not all the cases of memory loss are related with dementia. Dementia can occur when two or more functions of the brain are affected without losing one’s sense like memory, language, reasoning, judgment and so on.

Symptoms

The symptoms of dementia comprises of complexity of normal brain functioning of the cognitive skills that includes emotional behavior and personality, language, memory, perception and thinking and judgment.

Typical symptoms seen in an individual with dementia include:

  • Memory loss
  • Difficulty communicating, complex tasks, planning and organizing, coordination and motor functions
  • Orientation troubles causing them to get lost frequently
  • Changes in personality and unexpectedly inappropriate behaviour
  • Inability to reason
  • Paranoia
  • Agitation
  • Hallucinations

Conventional treatment options

Progressive dementia like Alzheimer’s disease has no possible cure or treatment that can stop its progression. Though there are some drug treatments that can momentarily improve the symptoms. Several of the drugs presently accepted by the U.S. Food and Drug Administration (FDA) for AD are placed in a category known as cholinesterase inhibitors. These drugs decrease the working of the neurotransmitter acetylcholine. At present, there are four cholinesterase inhibitors accepted for use in the United States like tacrine (Cognex), donepezil (Aricept), rivastigmine (Exelon), and galantamine (Reminyl). These drugs improvises the cognitive skills of a person momentarily. Most of the dementia symptoms and behavioral problems can be treated primarily with the use of nondrug approaches. With the help of physical therapy and occupational therapy, patients will be able to deal with changes in behavior and normal daily activities.

Causes of Dementia

Dementia occurs due to the injury to the brain cells. Correspondence between brain cells as a result of this damage. This disallows the brain cells to communicate normally affecting the thinking and behavioral signs.
Dementia can be categorized into different types based upon its common features. The frequently used classifications are:

Cortical dementia has an effect on the outer layer (cortex) of the brain alone

Sub cortical dementia  has an effect on the lower layer of the cortex

Progressive dementia this condition worsen with time, slowly causing an increased obstruction with cognitive abilities

Primary dementia is not a consequence of any other disease

Secondary dementia caused due to an outcome of a physical injury

Progressive dementia normally occurs in people with Alzheimer’s disease, Lewy body dementia and vascular dementia. The most common type of progressive dementia is Alzheimer’s disease. Dementia is also caused due to disorders like Huntington’s disorder, Traumatic Brain Injury, Multiple sclerosis and Parkinson’s disease. Several dementias that take place are wavering and visible in the case of immune disorders, metabolic disorders, nutritional deficiency and reactions to certain medications.

Dementia Stem Cell Treatment

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STEM CELL THERAPY FOR DEMENTIA

Stem cell therapy can generate newer cells to repair damage and restore the lost cells in the brain to offer a clear cut therapy option for dementia. It has been proven in various clinical trials that the bone marrow derived mesenchymal stem cells can work together with the host brain cells and free some molecules that help support the development of new nerve cells including creating an environment to support their survival. They are also involved in neuro protection, angiogenesis and several other metabolic activities that may together help to improve the reasoning, thinking and memory abilities of individuals suffering from dementia.Stem cells exude a group of neurotrophins, growth factors and other supportive substances. This helps in improved continued existence of the neurons through facilitations of neuroprotective responses like angiogenesis, axonal guidance and regeneration. The progression of dementia can be delayed due to NeuroRehabilitation and Autologous Hematopoietic Stem Cell Transplantation.

Objective Radiological improvements after stem cell therapy in Dementia

Pre stem cell therapy. SPECT scan presenting hypometabolism in the brain as a whole, with purple areas depicting areas of hypometabolism and orange areas as areas of normal metabolism

Post stem cell therapy. SPECT scan presenting an increase in the orange area, which is the area of normal metabolism and reduction in the purple area.

Stem cell therapy. has a lot of possibility to stop the progression of dementia. It is a secure treatment and there is a marked improvement seen in the condition of the elderly patients.

How stem cell therapy works in dementia

Stem cell therapy. can generate new cells to repair damage and replace lost cells in the brain to give a well defined therapy option for dementia. Most clinical trials have shown that bone marrow derived mesenchymal stem cells, can interrelate with the host brain cells and release several molecules that promote the formation of new nerve cells, as well as to help create an environment that support their survival. They are also involved in neuro protection, angiogenesis and several other metabolic activities that may help to improve the reasoning, thinking and memory abilities of individuals suffering from dementia.

Stem cells have been revealed to produce a group of neurotrophins, growth factors and other supportive substances. This helps in better survival of the neurons through facilitation of neuroprotective responses like angiogenesis, axonal guidance and regeneration, which may further result in improved cognitive function.

Autologous Hematopoietic Stem Cell Transplantation along with NeuroRehabilitation can result in significant improvements and can definitely help in delaying the progression in the case of dementia.

The NeuroGen Outcome

We have treated patients suffering from several forms of dementia like Vascular, Alzheimer’s and Fronto temporal dementia. We take care of each individual need and provide a customized approach for each one of them. Our patients are provided with the best of environment so that their whole session remains enriching.

As a result, our patients have shown a marked improvement in their functional and symptomatic conditions followed by the stem cell therapy. together with the extensive neurorehabilitation program. Improvements that have been seen are proper emotional responses, more cooperation, reduced crying spells, improved sitting tolerance and compliance to therapies improved. The chief improvements are also seen in cognitive functioning related to memory, attention, concentration, mathematical abilities and reasoning.These positive changes are recorded objectively on the neuropsychological test of Mini Mental Status Examination (MMSE).

Our patients are able to keep up with a routine and are free from dependency in their daily routine. On a physical evaluation, improvements in fine motor activities, localization of objects improved, oromotor control and swallowing movements are also seen.After the stem cell therapy, the most significant observation is that the development of the disease is cut short and the patients are able to live a more fulfilling life.

The improvements observed in the PET –CT scans of the patientsare further envisioned by the development seen in the metabolism of the affected area of the brain. This sheds a light on the transplanted stem cells that have the possibility to develop the damaged areas that results in further clinical and functional changes.

Your most common questions answered

My mother has a memory loss problem. Does it relate with dementia?

One of the most common symptoms for dementia is memory loss. However, not all memory loss problem cannot be directly linked with dementia. It could be the result of many other conditions, it is not possible to answer this question without a proper study of the case.

Is there a proper definition and cure for dementia?

Defining dementia is a complex one as it is a descriptive term for a number of symptoms that are caused by a number of neurological disorders. Dementia can be curable only if two or more brain functions like memory, language, judgments are affected without loss of consciousness.

Will Alzheimer’s lead to dementia? What are the other causes?

Yes in most cases. Alzheimer’s disease is a common type of progressive dementia. Advanced dementia is commonly seen in individuals with Alzheimer’s disease, Lewy body dementia and vascular dementia.Other disorders such as Huntington’s disorder, Traumatic Brain Injury, Multiple sclerosis and Parkinson’s disease can also lead to dementia.

What are the first signs and causes of dementia? How do I differentiate it?

Dementia occurs due to the damage of the brain cells. This damage hinder with the capability of brain cells to correspond with each other. When this happens, the thinking, behavior and feelings can get affected.

Dementia can be grouped into different types depending on their common features. The commonly used classifications will include:

  • Cortical dementia
  • Sub cortical dementia
  • Progressive dementia
  • Primary dementia
  • Secondary dementia

Does having dementia interfere with normal brain functioning?

Dementia symptoms interfere with normal brain functioning and the cognitive abilities like emotional behavior and personality, language, memory, perception and thinking and judgment.

What are the common symptoms of an individual with dementia?

Some of the common symptoms seen in an individual with dementia include memory loss, difficulty communicating, difficulty with complex tasks, difficulty with planning and organizing and Difficulty with coordination and motor functions.

Can these symptoms be treated off through medications alone?

The chief cause for the occurrence of dementia is the loss of brain cells. Currently, the pharmacological treatment is unable to prevent, cure and stop the disease progression. The symptoms can be improved through medications and supervised therapy but again it cannot repair and renew the loss of neurons that occurs. Now with the discovery of stem cell therapy, we can plan to control the disease progression.

How does stem cell therapy help in treating dementia?

Stem cell therapy can generate new cells to fix damage and restore lost cells in the brain to give a well defined therapy option for dementia.

How stem cells bring an improvement to cognitive functions?

Stem cells have been revealed to produce a group of neurotrophins, growth factors and other supportive substances. This helps in better survival of the neurons through facilitation of neuroprotective responses like angiogenesis, axonal guidance and regeneration, which may further result in improved cognitive function.

I came across a site that said that there are different types of dementia? Can you please elaborate on that?

Yes there are different types of dementia. Many individuals suffer from various types of dementia like Vascular, Alzheimer’s and Fronto temporal dementia. Each of these cases requires individual care and a tailor made adaption to meet their needs. We aspire to offer our patients in an environment that is healthy and enriching for them.

If someone wants to opt for the stem cell therapy for dementia; what are the benefits that one can get to feel?

Following our stem cell therapy combined with Neurorehabilitation program our patients have shown efficient and suggestive improvements in their conditions under the guidance of our team of expert doctors and therapists. The improvements seen in these cases are appropriate emotional responses, more cooperation, reduced crying spells, improved sitting tolerance and compliance to therapies improved.

Will stem cell therapy be able to deliver what it promises and generate a new hope in old people?

Yes stem cell therapy has a lot of prospective to stop the development of dementia. It is a safe treatment and improves the quality of life of elderly patients who are disillusioned thinking there is no cure for them.